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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Horm Behav. 2018 May 12;102:76–84. doi: 10.1016/j.yhbeh.2018.05.002

Figure 4.

Figure 4

Effects of previous exposure to continuous, unopposed estradiol or delayed ovariectomy on estrogen response element (ERE)-dependent gene expression in the hippocampus (A), cortex (B), and hypothalamus (C) of ovariectomized mice. Transgenic ERE-Luciferase reporter mice were sham ovariectomized (Previous Intact) or ovariectomized and implanted with capsules delivering continuous treatment with estradiol (Previous Estradiol) or vehicle alone (Previous Vehicle). After 40 days all capsules were removed and Previous Intact mice were ovariectomized. Brain tissue was harvested 28 days after termination of treatment. *p<0.05 vs. Previous Vehicle, #P<0.05 vs Previous Intact.