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. 2018 Jun 11;9:704. doi: 10.3389/fphys.2018.00704

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Copyright © 2018 Brouwers, Stephens, Costford, Hopf, Ayala, Yi, Xie, Li, Gardell, Sparks and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elevated NAMPT combined with exercise augments VO₂max. (A) Maximal aerobic capacity (VO₂max) following voluntary exercise training; (B) daily running distance during the voluntary exercise training protocol; (C) daily running time during the voluntary exercise training protocol; (D) daily average running speed during the voluntary exercise training protocol; (E) daily maximal running speed during the voluntary exercise training protocol. ^∗p < 0.05 NamptTg vs. WT.