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. 2018 Jun 11;9:704. doi: 10.3389/fphys.2018.00704

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Copyright © 2018 Brouwers, Stephens, Costford, Hopf, Ayala, Yi, Xie, Li, Gardell, Sparks and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elevated NAMPT combined with exercise augments skeletal muscle mitochondrial respiratory capacity. (A–E) Glycolytic substrates supported (A) LEAK respiration, (B) complex I oxidative phosphorylation (OXPHOS) respiration (OXPHOS_CI), (C) complex II OXPHOS respiration (OXPHOS_CII), (D) maximal (complex I+II) OXPHOS respiration (OXPHOS_CI+II), (E) election transfer system (ETS) capacity or maximal uncoupled respiration (Uncoupled_ETS) in gastrocnemius muscle of NamptTg and WT mice following voluntary exercise training. (F–J) Fatty acid substrates supported (F) LEAK respiration, (G) OXPHOS_CI, (H) OXPHOS_CII, (I) Max OXPHOS_CI+II, and (J) Uncoupled_ETS in gastrocnemius muscle of NamptTg and WT mice following voluntary exercise training. ^∗p < 0.05 NamptTg vs. WT.