Table 1.
Gene ontology (GO)-categorized and differentially regulated genes by elevated NAD+ levels and training in red quadriceps (exercised NamptTg vs. exercised WT).
| Gene ontology (GO) term | Count | % | P-value | Fold enrichment |
|---|---|---|---|---|
| Acetyl-CoA metabolic process | 6 | 0.701 | 9.3E-3 | 4.542 |
| Glycolysis | 7 | 0.818 | 1.0E-2 | 3.734 |
| Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region | 3 | 0.351 | 4.0E-2 | 9.087 |
| Cellular response to hydrogen peroxide | 3 | 0.351 | 8.9E-2 | 5.867 |
| NADH dehydrogenase activity | 3 | 0.351 | 2.5E-1 | 3.093 |
| Peroxidase | 3 | 0.351 | 2.5E-1 | 3.141 |
Count, the number of genes regulated by elevated NAD+ levels and training in a gene ontology biological process; %, percentage of the genes that belong to a biological process (GO term) to the total number of significantly regulated gene; fold enrichment, the overall enrichment score for the group of genes based on the modified Fisher Exact p-value test. The higher the score, the more enriched.