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. 2018 Jun 11;9:1331. doi: 10.3389/fimmu.2018.01331

Figure 4.

Figure 4

Ex vivo analysis of differentially expressed validated microRNAs (miRNAs) in mouse spleens. C57BL/6 mice were infected intraperitoneally at 1, 3, or 6 days post-infection, and the relative expression of miRNAs: (A) mmu-miR-151-3p, (B) mmu-miR-155-5p, (C) mmu-miR-181a-5p, (D) mmu-miR-328-3p, (E) mmu-miR-21a-5p, (F) mmu-miR-98-5p, (G) mmu-miR-145a-3p, (H) mmu-miR-146b-5p, and (I) mmu-miR-374b-5p were evaluated in mouse spleens. miRNAs expression were assessed by real-time PCR and were normalized to SNOR61. Error bars represent the mean ± SD. Similar results were obtained in two independent experiments. Statistically significant differences of miRNAs expression from infected mice compared with non-infected mice (0) are denoted by an asterisk (p < 0.05), # (p < 0.05) represents statistically significant differences compared with 1 day post-infection, and & represents statistically significant differences compared with 3 day post-infection with B. abortus.