Table 5.
KEGG pathways of target genes of 16 microRNAs (miRNAs) differentially expressed in cells treated with serum from healthy individuals compared with head and neck squamous cell carcinomas patients.
| KEGG pathway | P-value | Genesa | miRNAsb |
|---|---|---|---|
| Pathways in cancer | 1.23E−02 | 95 | 11 |
| PI3K-AKT signaling pathway | 3.38E−02 | 82 | 12 |
| HTLV-I infection | 3.24E−02 | 68 | 12 |
| Focal adhesion | 2.35E−03 | 62 | 11 |
| Proteoglycans in cancer | 1.51E−06 | 60 | 12 |
| Epstein–Barr virus infection | 9.00E−03 | 58 | 12 |
| Viral carcinogenesis | 1.80E−03 | 56 | 11 |
| Endocytosis | 2.51E−02 | 52 | 11 |
| FOXO signaling pathway | 2.35E−03 | 46 | 11 |
| Hepatitis B | 3.62E−03 | 46 | 12 |
| Protein processing in endoplasmic reticulum | 2.51E−02 | 45 | 10 |
| RNA transport | 4.32E−02 | 44 | 11 |
| Ubiquitin-mediated proteolysis | 2.48E−02 | 41 | 10 |
| Cell cycle | 2.35E−03 | 40 | 10 |
| Transcriptional misregulation in cancer | 4.32E−02 | 40 | 10 |
| Signaling pathways regulating pluripotency of stem cells | 3.43E−02 | 39 | 11 |
| Thyroid hormone signaling pathway | 8.07E−03 | 37 | 11 |
| Neurotrophin signaling pathway | 1.38E−02 | 36 | 11 |
| AMPK signaling pathway | 4.32E−02 | 36 | 11 |
| Oocyte meiosis | 1.69E−04 | 35 | 10 |
| Small cell lung cancer | 4.01E−04 | 33 | 10 |
| Choline metabolism in cancer | 5.34E−03 | 33 | 10 |
| Prostate cancer | 2.35E−03 | 32 | 11 |
| Adherens junction | 7.74E−07 | 30 | 10 |
| Estrogen signaling pathway | 3.62E−03 | 30 | 11 |
| Bacterial invasion of epithelial cells | 9.64E−05 | 29 | 10 |
| Erbb signaling pathway | 1.62E−02 | 29 | 9 |
| Chronic myeloid leukemia | 4.96E−04 | 28 | 10 |
| Progesterone-mediated oocyte maturation | 3.28E−02 | 28 | 12 |
| Salmonella infection | 4.05E−02 | 27 | 11 |
| Glioma | 3.37E−06 | 26 | 9 |
| Colorectal cancer | 6.49E−05 | 26 | 11 |
| Apoptosis | 7.44E−03 | 24 | 9 |
| P53 signaling pathway | 9.00E−03 | 24 | 10 |
| Prolactin signaling pathway | 9.00E−03 | 24 | 10 |
| Non-small cell lung cancer | 1.69E−04 | 23 | 10 |
| Shigellosis | 2.35E−03 | 23 | 10 |
| Pancreatic cancer | 3.42E−03 | 23 | 9 |
| Renal cell carcinoma | 3.50E−02 | 22 | 8 |
| Epithelial cell signaling in helicobacter pylori infection | 4.62E−02 | 22 | 7 |
| Melanoma | 2.96E−02 | 21 | 8 |
| Endometrial cancer | 2.35E−03 | 20 | 11 |
| Central carbon metabolism in cancer | 3.24E−02 | 20 | 8 |
| Synaptic vesicle cycle | 3.38E−02 | 18 | 7 |
| Bladder cancer | 1.61E−02 | 15 | 7 |
| Lysine degradation | 3.38E−02 | 12 | 6 |
| Thyroid cancer | 5.23E−03 | 11 | 7 |
| Fatty acid metabolism | 5.16E−03 | 9 | 9 |
aNumber of genes in each pathway targeted by miRNAs.
bNumber of miRNAs targeting genes in each pathway.