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. 2018 Jun 11;11:178. doi: 10.3389/fnmol.2018.00178

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Copyright © 2018 Gopurappilly, Deb, Chakraborty and Hasan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STIM1 knockdown represses proliferation of NPCs. (A) Control (NTC transduced) cells expressing ZsGreen. (B) STIM1 knockdown NPCs undergo spontaneous differentiation as evident by the presence of neurite-like processes and branches. (C,D) Neurosphere forming assay (NSA) of NTC and STIM1 knockdown NPCs at 48 h. (E) Quantification of neurosphere (NS) numbers per well after a week of seeding NTC and STIM1 knockdown NPCs (n = 3, p = 0.0008). (F) Quantification of NS size in microns (μm) at day 7 (n = 4, p = 0.00067). (G) Skeletonized (ImajeJ) NS to show the size difference at day 7 of representative NTC and STIM1 knockdown NPCs. Scale bar-50 μm (A–D), 20 μm (G).