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. 2018 Jun 11;11:198. doi: 10.3389/fnmol.2018.00198

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Copyright © 2018 Min, Tang, Hu, Zhu, Ma, Zha, Deng, Yan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cosmosiin differentially affects ADAM10 immunofluorescent intensity in SH-SY5Y and HT22 cells. (A,B) Representative confocal microscopic images (A) and quantification (B) of immunofluorescence intensity of ADAM10 (green) in human SH-SY5Y cells in the absence (treated with DMSO only) and presence of cosmosiin (5 μM for 36 h). (C,D) Representative confocal microscopic images (C) and quantification (D) of immunofluorescence intensity of ADAM10 (green) in murine HT22 cells in the absence (treated with DMSO only) and presence of cosmosiin (5 μM for 36 h). DAPI (blue), a nuclear marker, served as internal control. Cosmosiin significantly increases immunofluorescence signals of ADAM10 in SH-SY5Y but not in HT22 cells. Scale bar, 25 μm. **P < 0.01 (n = 50).