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. 2018 Jun 11;11:198. doi: 10.3389/fnmol.2018.00198

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Copyright © 2018 Min, Tang, Hu, Zhu, Ma, Zha, Deng, Yan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cosmosiin affects amyloid precursor protein (APP) processing and Aβ production. (A) Representative Western blots (left) and bar plot summary (right) of full-length APP (APP-FL), ADAM10, BACE1, α-/β-CTF, sAPPα and sAPPβ levels in HEK-APP cells treated with the vehicle DMSO (1:10,000) or 5 μM cosmosiin for 36 h. (B) Normalized levels of Aβ1–40 (left) and Aβ1–42 (right) measured by enzyme-linked immunosorbent assay (ELISA) in the culture medium of HEK-APP cells treated with the vehicle DMSO (1:10,000) or cosmosiin (1, 5 and 10 μM) for 36 h. Data are expressed as means ± SD. *P < 0.05; **P < 0.01 (n = 4).