Table 2.
EC50 of Plasmodium falciparum clones
| EC50, nM | ||||||||
| Clone | Selection agent | PfCytB mutation | ATQ | CK-2-68 | RYL-552 | AMA | DSM1 | CQ |
| Controls | ||||||||
| HB3 | 0.4 ± 0.1 | 44 ± 3 | 17 ± 0.1 | 381 ± 78 | 69 ± 6 | 3.1 ± 0.4 | ||
| 3D7 | 0.7 ± 0.1 | 34 ± 4 | 22 ± 3 | 250 ± 15 | 155 ± 8 | 12 ± 2 | ||
| Dd2 lineage | ||||||||
| Dd2 | 0.4 ± 0.02 | 57 ± 3 | 18 ± 2 | 221 ± 58 | 134 ± 22 | 214 ± 31 | ||
| DA-3H6M133I | ATQ | M133I | 10 ± 2 | 61 ± 9 | 3.3 ± 1 | 243 ± 25 | 207 ± 21 | 244 ± 40 |
| DA-4K272R | ATQ | K272R | 55 ± 7 | 12 ± 4 | 11 ± 3 | 45 ± 5 | 155 ± 31 | 209 ± 37 |
| DR-4H5F264L | RYL-552 | F264L | 1.1 ± 0.2 | 71 ± 12 | 91 ± 7 | 63 ± 15 | 137 ± 16 | 201 ± 21 |
| 106/1 lineage | ||||||||
| 106/1 | 1.1 ± 0.1 | 69 ± 7 | 50 ± 5 | 417 ± 58 | 189 ± 13 | 28 ± 0.2 | ||
| 6A-4F12Y268S | ATQ | Y268S | 6,760 ± 1,600 | 38 ± 2 | 75 ± 10 | 108 ± 16 | 93 ± 27 | 39 ± 3 |
| 6C-2A7A122T | CK-2-68 | A122T | 0.7 ± 0.1 | 225 ± 16 | 50 ± 4 | 208 ± 12 | 221 ± 57 | 20 ± 2 |
| 6R-3H8V259L | RYL-552 | V259L | 8.2 ± 0.5 | 209 ± 7 | 202 ± 17 | 137 ± 22 | 98 ± 48 | 32 ± 2 |
| 6R-4E5A122T | RYL-552 | A122T | 0.7 ± 0.1 | 220 ± 6 | 158 ± 2 | 293 ± 36 | 107 ± 23 | 30 ± 3 |
Mean ± SD; n = 3–7.