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Model of Doc2-dependent synaptic augmentation. In basal conditions, only a small portion of SVs in the RRP are superprimed. Augmentation is induced when synapses are stimulated by a series of action potentials (APs), resulting in the accumulation of residual Ca2+. This Ca2+ binds to the C2B domain of Doc2, triggering the translocation of the Doc2–munc13 complex to the plasma membrane. At the plasma membrane, the complex drives superpriming of a subset of SVs.
