Table 1.
Clinicopathological characteristics.
| Variable | hrHPV−, N = 158 (%) | hrHPV+,N = 52 (%) | Total, N = 213 (%)a | p-Valueb |
|---|---|---|---|---|
| Age median (IQR) | 67.6 (58.2–74.6) | 63.6 (54.4–71.6) | 65.9 (57.3–74.4) | 0.38 |
| pT stage | 0.17 | |||
| pT1 | 42 (26.6) | 19 (36.5) | 61 (28.6) | |
| pT2 | 99 (62.7) | 28 (53.8) | 130 (61.0) | |
| pT3 | 11 (7.0) | 5 (9.6) | 16 (7.5) | |
| pT4 | 6 (3.8) | – | 6 (2.8) | |
| Tumor size median (IQR) | 3.0 (2.0–4.1) | 2.5 (1.5–3.9) | 3.0 (2.0–4.0) | 0.09 |
| Histological subtype | 0.08c | |||
| SCC NOS | 137 (87.3) | 43 (82.7) | 180 (84.5) | |
| Papillary | 8 (5.1) | 1 (1.9) | 9 (4.2) | |
| Verrucous | 5 (3.2) | – | 5 (2.3) | |
| Warty | 2 (1.3) | 3 (5.8) | 5 (2.3) | |
| Basaloid | 1 (0.6) | 4 (7.7) | 5 (2.3) | |
| Mixed SCC-basaloid | 1 (0.6) | 1 (1.9) | 2 (0.9) | |
| Sarcomatoid | 1 (0.6) | – | 1 (0.5) | |
| Cuniculatum | 1 (0.6) | – | 1 (0.5) | |
| Pseudohyperplastic | 1 (0.6) | – | 1 (0.5) | |
| Missing | 1 (0.6) | – | 4 (1.9) | |
| Grade of differentiation | <0.01 | |||
| Well (grade 1) | 70 (44.3) | 9 (17.3) | 80 (37.6) | |
| Intermediate (grade 2) | 62 (39.2) | 31 (59.6) | 94 (44.1) | |
| Poor (grade 3) | 26 (16.5) | 12 (23.1) | 38 (17.8) | |
| Missing | – | – | 1 (0.5) | |
| pN stage | 0.84 | |||
| pN0 | 107 (67.7) | 36 (69.2) | 145 (68.1) | |
| pN+ | 51 (32.3) | 16 (30.8) | 68 (31.9) | |
| Extranodal growth | 0.12d | |||
| Present | 19 (12.0) | 3 (5.8) | 22 (10.3) | |
| Absent | 28 (17.7) | 13 (25) | 42 (19.7) | |
| No LNM | 107 (67.7) | 36 (69.2) | 145 (68.1) | |
| Missing | 4 (2.5) | – | 4 (1.9) | |
| Death by penile cancer | 0.02 | |||
| No | 131 (82.9) | 50 (96.2) | 184 | |
| Yes | 27 (17.1) | 2 (3.8) | 29 |
IQR, interquartile range (25th–75th percentile); SCC, squamous cell carcinoma; NOS, not otherwise specified; HPV, human papilloma virus; LNM, lymph node metastases.
aIncluding three cases with unknown hrHPV status.
bExcluding missing cases. Comparing the two hrHPV subgroups. Independent sample t-test for continuous variables, chi-square, or Fishers exact test for categorical variables.
cDivided in SCC NOS, unfavorable subtypes (basaloid, mixed basaloid-warty, and sarcomatoid) and favorable subtypes (papillary, verrucous, warty, cuniculatum, and pseudohyperplastic).
dExcluding patients with no LNM/unknown lymph node status.
Bold numbers are statistically significant.