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. 2018 Jun 11;9:1319. doi: 10.3389/fimmu.2018.01319

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Copyright © 2018 Lutzky, Ratnatunga, Smith, Kupz, Doolan, Reid, Thomson, Bell and Miles.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Divergence of CD8⁺ T cell cytokine profiles in immunocompetent individuals with active non-tuberculous mycobacteria (NTM) infection. (A) Flow cytometric analysis of ex vivo CD8⁺ T cells showed significantly more IFNγ⁻ TNFα⁺ cells (P = 0.01) and IL2⁻ TNFα⁺ cells (P = 0.048) in NTM^Act compared to HC^B. (B) Polyfunctionality profiling of CD8⁺ T cells shown in pie charts were not significantly different between the two groups. However, significantly higher TNFα mono-functional CD8⁺ T cells were observed in NTM patient group (P = 0.002). (C) SPICE dot plots show polyfunctionality profile of all combinations of cytokine expression in CD8⁺ T cells after PMA/I stimulation between NTM^Act and HC^B groups. Significantly different expression compared to HC^B (Wilcoxon rank test P < 0.05) is indicated with # symbol.