Table 1.
Table shows demographic of cystic fibrosis (CF) cohorts and elderly patient group.
| CFAct | CFPast | CFControls | NTMAct | |
|---|---|---|---|---|
| Mean age (SD) | 32.6 (13.6) | 34.9 (10.4) | 33.1 (8.0) | 75.6 (9.23) |
| Male:female | 06:01 | 06:02 | 06:03 | 03:07 |
| Non-tuberculous mycobacteria (NTM) infection at time of sample | MABS (6) MAC (1)a | None | None | MABS (10) |
| History of NTM infection | ||||
| MABS | 0 | 8 | 0 | 0 |
| MAC | 3b | 0 | 0 | 3c |
| Other infections | ||||
| Pseudomonas aeruginosa | 5 | 8 | 9 | 4 |
| Aspergillus spp | 0 | 0 | 0 | 1 |
| Burkholderia sppd | 0 | 1 | 1 | 0 |
| Lung function | ||||
| >70% FEV1 | 4 | 1 | 3 | 8 |
| 30–70% FEV1 | 3 | 6 | 5 | 2 |
| <30% FEV1 | 0 | 1 | 1 | 0 |
| Radiographic features | ||||
| Bronchiectasis | 7 | 8 | 9 | 10 |
CFAct-CF patients with active NTM infection. CFPast-CF patients with past NTM infection. Both groups of patients had a history of P. aeruginosa infection. CFControls-control CF patients with chronic P. aeruginosa infection. NTMAct-elderly patients with active NTM infection. N/A, not applicable; MABS, Mycobacterium abscessus complex; MAC, Mycobacterium avium complex.
aOne patient in CFAct group had active MAC infection. This patient was excluded from ANOVA and biomarker analysis but included in general profiling analysis. Data point is shown as a blue circle in scatter plots for ANOVA analysis in Figures 1A and 2A.
bOne patient in CFAct group had prior history of MAC infection while two subsequently developed MAC infection.
cIn NTMAct elderly patient group, one patient had a history of MAC infection prior to MABS infection while two others developed MAC infection after treatment of current episode of MABS infection.
dBurkholderia cepecia complex.