Table 1.
Baseline characteristics
|
Stenting group |
Endarterectomy group |
||||
|---|---|---|---|---|---|
| Included in analyses | All patients | Included in analyses | All patients | ||
| Demographics | |||||
| Age (years) | 70·0 (63·6–76·5) | 70·8 (64·4–76·9) | 70·6 (64·1–76·9) | 70·8 (64·1–76·9) | |
| Men | 513/737 (70%) | 601/853 (70%) | 561/793 (71%) | 606/857 (71%) | |
| Women | 224/737 (30%) | 252/853 (30%) | 232/793 (29%) | 251/857 (29%) | |
| Vascular risk factors and history | |||||
| Treated hypertension | 503/730 (69%) | 587/843 (70%) | 552/787 (70%) | 596/851 (70%) | |
| Systolic blood pressure (mm Hg) | 147·4 (24·1) | 147·0 (24·0) | 146·0 (23·7) | 146·0 (23·6) | |
| Diastolic blood pressure (mm Hg) | 79·3 (11·8) | 79·2 (11·7) | 78·2 (12·6) | 78·3 (12·7) | |
| Diabetes | 162/737 (22%) | 184/853 (22%) | 165/793 (21%) | 188/857 (22%) | |
| Non-insulin dependent | 116/730 (16%) | 134/843 (16%) | 128/787 (16%) | 147/851 (17%) | |
| Insulin dependent | 46/730 (6%) | 50/843 (6%) | 37/787 (5%) | 41/851 (5%) | |
| Treated hyperlipidaemia | 459/730 (63%) | 522/843 (62%) | 523/787 (66·5) | 563/851 (66%) | |
| Total cholesterol (mmol/L) | 4·9 (1·3) | 4·8 (1·3) | 4·9 (1·3) | 4·9 (1·3) | |
| Current smoker | 182/730 (25%) | 205/843 (24%) | 183/787 (23%) | 198/851 (23%) | |
| Ex-smoker | 352/730 (48%) | 408/843 (48%) | 392/787 (50%) | 424/851 (50%) | |
| Angina in past 6 months | 70/730 (10%) | 83/843 (10%) | 69/787 (9%) | 77/851 (9%) | |
| Previous myocardial infarction | 126/730 (17%) | 151/843 (18%) | 145/787 (18%) | 156/851 (18%) | |
| Previous coronary-artery bypass graft | 95/730 (13%) | 109/843 (13%) | 106/787 (13%) | 116/851 (14%) | |
| Atrial fibrillation | 44/730 (6%) | 57/843 (7%) | 52/787 (7%) | 59/851 (7%) | |
| Other cardioembolic source | 15/730 (2%) | 19/843 (2%) | 16/787 (2%) | 16/851 (2%) | |
| Cardiac failure | 21/730 (3%) | 23/843 (3%) | 40/787 (5%) | 47/851 (6%) | |
| Peripheral artery disease | 123/730 (17%) | 139/843 (16%) | 122/787 (16%) | 136/851 (16%) | |
| Degree of symptomatic carotid stenosis* | |||||
| 50–69% | 75/737 (10%) | 92/853 (11%) | 71/793 (9%) | 76/857 (9%) | |
| 70–99% | 662/737 (90%) | 761/853 (89%) | 722/793 (91%) | 781/857 (91%) | |
| Degree of contralateral carotid stenosis* | |||||
| <50% | 495/737 (67%) | 565/853 (66%) | 522/793 (66%) | 561/857 (65%) | |
| 50–69% | 104/737 (14%) | 128/853 (15%) | 131/793 (17%) | 142/857 (17%) | |
| 70–79% | 93/737 (13%) | 105/853 (12%) | 99/793 (12%) | 110/857 (13%) | |
| Occluded | 43/737 (6%) | 49/853 (6%) | 35/793 (4%) | 37/857 (4%) | |
| Unknown | 2/737 (<1%) | 6/853 (1%) | 6/793 (1%) | 7/857 (1%) | |
| Most recent ipsilateral event before randomisation† | |||||
| Retinal ischaemia (amaurosis fugax or retinal infarct) | 157/728 (22%) | 174/840 (21%) | 153/781 (20%) | 165/844 (20%) | |
| Transient ischaemic attack | 239/737 (32%) | 273/853 (32%) | 280/793 (35%) | 303/857 (35%) | |
| Ischaemic hemispheric stroke | 332/737 (45%) | 393/853 (46%) | 348/793 (44%) | 376/857 (44%) | |
| Unknown | 9/737 (1%) | 13/853 (2%) | 12/793 (2%) | 13/857 (2%) | |
| Time from event to procedure (days) | 35 (15–82) | 35 (15–82) | 40 (18–87) | 40 (18–87) | |
| Treatment within 14 days of event | 181/737 (25%) | 206/837 (25%) | 144/791 (18%) | 151/834 (18%) | |
Data are either median (IQR), number of patients/total number (%), or mean (SD). Some totals do not add up to 100% because of rounding.
*
Degree of stenosis reported by randomising centre according to the measure used in the North American Symptomatic Carotid Endarterectomy Trial or a non-invasive equivalent.
†
If two events were reported on the same day, the more severe event was counted.