Table 5. SAR of R¹ Substitution: Analogs 73–106.

^aValues with standard deviation (SD) represent the average from at least three experiments.

^bRLM represents rat liver microsomal stability conducted at NCATS in the presence of NADPH.

^cCompounds noted as >57 μM represent a very weak or no inhibition [efficacy of ≤50% of full inhibition at highest tested concentration (57 μM)].