Table 7. Pharmacokinetics (PK) of Compounds 86 and 91.

compda	routeb	speciesc	Cmax (ng/mL)d	t1/2 (h)	AUC0–∞ (h·ng/mL)	Vss (L/kg)	CLp (mL/min/kg)	F (%)
86	iv	mouse	2350	0.3	1141	0.7	30
86	po	mouse	1234	1.6	2518			44
91	iv	mouse	1997	1.3	1830	1.4	18
91	po	mouse	1530	2.2	6980			76
91	iv	rat	2587	1.5	3160	0.7	11
91	po	rat	1980	3.5	7536			48

^an = 3. The compound was formulated as solution in 20% HP-β-CD in saline.

^bDosage: 2 mg/kg for intravenous (iv) and 10 mg/kg for oral (po) administration. Plasma samples were measured for drug exposure by LC–MS/MS.

^cCD-1 mouse or Sprague-Dawley rat were used.

^dThe maximum drug concentration (C_max) was observed at t = 5 min, the first sampling time point after iv administration.