Table 1. IC50 Values for NHH Carbamate Inhibitors of NOTUM Determined by Competitive Gel-Based ABPPa.
compd | IC50 [nM] (95% CI) |
---|---|
ABC28 | 677 (467–943) |
ABC63 | 1506 (1101–2065) |
ABC90 | 290 (221–441) |
ABC91 | >10 μM |
ABC92 | 200 (156–275) |
ABC99 | 13 (9.39–17.5) |
ABC101 | >10 μM |
Data represent average values with confidence intervals (CI) provided for three independent experiments.