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. 2018 Apr 2;9(6):528–533. doi: 10.1021/acsmedchemlett.8b00018

Table 1. Statistics of Half-Life Change for MMP Analysesa.

MMP Δthalf (h) p-value N MMP Δthalf (h) p-value N
H → F +0.12 2.7 × 10–6 4539 H → CF3 +0.34 9.9 × 10–10 524
2H → 2F +0.35 4.2 × 10–5 573 Me → Cl +0.21 4.7 × 10–5 555
3H → 3F +0.99 4.9 × 10–5 78 Ph → Py –0.20 6.8 × 10–11 2419
H → Me +0.00 0.72 5377 H → OH –0.28 7.9 × 10–9 595
H → Cl +0.27 2.8 × 10–9 1255 H → COOH –0.74 9.8 × 10–9 79
a

N corresponds to number of MMPs.