FIGURE 1:

Pick1 cKO mice are glucose-intolerant. (a–c) Adult WT male mice aged 4–5 mo and their Pick1 cKO littermates were examined to determine body weight and water and food intake, n = 5. (d, e) Glucose and insulin were measured under fed and fasted conditions, n = 8. (f) OGTT was performed on male WT and Pick1 cKO mice after a 16-h fast, n = 5. (g) ITT was performed on male WT and Pick1 cKO mice after a 2-h fast, n = 5. Data are represented as mean ± SEM. *p < 0.05, **p < 0.01; two-sided Student’s t test.