FIGURE 4:

Elevated proinsulin in islets and serum from Pick1 cKO mice. (a–d) Proinsulin and proinsulin/insulin levels from WT and Pick1 cKO serum (a and b, n = 8) and isolated islets (c and d, n = 3, three groups per type of mouse, 10–20 islets per group). (e) Secreted proinsulin level stimulated with 2.8 or 16.7 mM Glc, n = 3. (f–h) mRNA and protein levels of PC1/3, PC2, and CPE from isolated islets of WT and Pick1 cKO mice. Data are represented as mean ± SEM. *p < 0.05, **p < 0.01; two-sided Student’s t test.