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. Author manuscript; available in PMC: 2018 Nov 6.
Published in final edited form as: Mol Pharm. 2017 Oct 3;14(11):4042–4051. doi: 10.1021/acs.molpharmaceut.7b00710

Figure 1. HDL NPs induce B cell lymphoma cell death through modulation of cellular cholesterol.

Figure 1

(a) HDL NPs (solid line) potently induce cell death in the GC DLBCL cell line SUDHL4, but not the ABC DLBCL cell lines TMD8 or HBL-1. Human HDL (dotted line) does not induce lymphoma cell death. *p<0.05 v. PBS control. (b), (c) HDL NPs efflux cholesterol from SUDHL4 (b) and TMD8 (c) cells. Antibody blockade of SCARB1 reduced cholesterol efflux in both cell lines, while addition of an isotype control antibody had no effect. *p<0.05 v. No antibody. (d) Total cholesterol content, normalized to cell number, of SUDHL4, TMD8 and HBL-1 cells treated with PBS or HDL NPs. *p<0.05 v. 0nM HDL NP.