Table 2.
Characterization of Class1 integrons and gene cassettes in 30 MDR isolates of integron-carrying Citrobacter.
| Isolates | Source | Hospital Ward | Antibiotic resistance profile | intI | Size of gene cassettes (bp) | Gene Cassettes |
|---|---|---|---|---|---|---|
| S1 | Urine | Surgery | AP/CTX/CPD/CAZ/CRO/CIP/CZ/ATM/S/ SXT | + | 750 | dfrA15-aadA1 |
| S75 | Urine | Surgery | AP/CIP/SXT/S | + | 750 | dfrA15-aadA1 |
| S2 | Urine | Internal | AP/CTX/CPD/CAZ/CRO/CZ/ATM/S/SXT/TN/GM | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S6 | Urine | Emergency | AP/CZ/SXT/S | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S14 | Urine | Internal ICU | AP/CTX/CPD/CAZ/CRO/TN/CIP/CZ/ATM/S/SXT | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S17 | Urine | Surgery | AP/CAZ/CZ | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S26 | Urine | Surgery | AP/CTX/CRO/CZ | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S84 | Respiratory secretions | Infectious | AP/CTX/CPD/CAZ/CRO/PTZ/CZ/SXT/S | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S86 | Blood | Pediatric | AP/CTX/CZ/S | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S94 | Stool | Infectious | AP/CTX/CPD/CAZ/ TN/ CZ | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S97 | Urine | Surgery | AP/TN/CZ | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S99 | Urine | Pediatric | AP/CZ/S | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S100 | Urine | Surgery | AP/CAZ/CZ/S | + | 1600, 1000 | dfrA1-aadA1, aadA1 |
| S8 | Urine | Surgery | AP/CTX/CPD/CAZ/CRO/CIP/CZ/ATM | + | 700 | Hypothetical protein |
| S10 | Urine | Emergency | AP/CTX/CAZ/CPD/CRO/CZ/SXT/S | + | 1600 | dfrA1-aadA1 |
| S32 | Stool | Internal | AP/CPD/CZ | + | 1600 | dfrA1-aadA1 |
| S42 | Respiratory secretions | Surgery | AP/CTX/CAZ/CPD/CRO/TN/GM/IMI/CZ/ S | + | 1600 | dfrA1-aadA1 |
| S47 | Respiratory secretions | Infectious | AP/CTX/CAZ/CPD/CRO/TN/GM/IMI/CZ/SXT/S | + | 1600 | dfrA1-aadA1 |
| S60 | Urine | Surgery ICU | CRO/CZ/SXT/S | + | 1600 | dfrA1-aadA1 |
| S67 | Wound | Surgery | AP/CTX/CRO/CIP/PTZ/IMI/ATM/MEM/SXT/S | + | 1600 | dfrA1-aadA1 |
| S46 | Respiratory secretions | NICU | AP/CZ/SXT/S | + | 1700, 1600, 1000, 750 | dfrA12-orfF-aadA2, dfrA1-aadA1, aadA1, dfrA15-aadA1 |
| S92 | Stool | Infectious | AP/TN/CZ/SXT/S | + | 1700, 1600, 1000, 750 | dfrA12-orfF-aadA2, dfrA1-aadA1, aadA1, dfrA15-aadA1 |
| S54 | Urine | Surgery | AP/CZ/SXT/SXT/S | + | 1700, 1600, 1000, 600, 500 | dfrA12-orfF-aadA2, dfrA1-aadA1, aadA1, Hypothetical protein |
| S88 | Blood | Infectious | AP/TN/CZ/SXT/S | + | 1700, 1600, 1000, 600, 500 | dfrA12-orfF-aadA2, dfrA1-aadA1, aadA1, Hypothetical protein |
| S91 | Blood | Surgery | AP/CTX/CPD/TN/CZ/SXT/S | + | 1700, 1600, 1000, 600, 500 | dfrA12-orfF-aadA2, dfrA1-aadA1, aadA1, Hypothetical protein |
| S73 | Urine | Infectious | AP/CRO/CZ/SXT/S | + | 1700, 1600 | dfrA12-orfF-aadA2, dfrA1-aadA1 |
| S85 | Urine | Surgery | AP/CPD/TN/CZ/SXT | + | 1700, 1600 | dfrA12-orfF-aadA2, dfrA1-aadA1 |
| S79 | Stool | Surgery | AP/CPD/CZSXT/S/SXT | + | 1700, 1600, 1000, 750, 700, 500 | dfrA12-orfF-aadA2, dfrA1-aadA1, aadA1, dfrA15-aadA1, Hypothetical protein |
| S80 | Urine | Surgery | AP/CPD/CAZ/CIP/CZ/SXT/S | + | 1700, 1600, 1000, 750, 700, 500 | dfrA12-orfF-aadA2, dfrA1-aadA1, aadA1, dfrA15-aadA1, Hypothetical protein |
| S89 | Blood | Pediatric | AP/CPD/CZ/S | + | 1700, 1600, 1000, 750, 700, 500 | dfrA12-orfF-aadA2, dfrA1-aadA1, aadA1, dfrA15-aadA1, Hypothetical protein |
SXT: Trimethoprim-sulfamethoxazole, CIP: Ciprofloxacin, TN: Tobramycin, GM: Gentamicin, CRO: Ceftriaxone, CTX: Cefotaxime, CAZ: Ceftazidime, ATM: Aztreonam, AP: Ampicilin, S: Streptomycin, CZ: Cefazolin, CPD: Cefpodoxime.