. 2018 Apr 11;15(6):9101–9109. doi: 10.3892/ol.2018.8461

Table II.

Univariate and multivariate analyses of the overall survival (OS) and disease-free survival (DFS) in patients with colorectal cancer.

	HR (95%CI)	p^a	HR (95%CI)	p^a	HR (95%CI)	p^a	HR (95%CI)	P^a
	Overall survival univariate		OS multivariate		Disease-free survival univariate		DFS multivariate

miR-888
Low	–		–		–		–
High	5.42 (3.69, 11.55)	0.005^a	4.89 (2.44, 9.08)	0.008^a	6.01 (2.85, 11.75)	0.018^a	5.37 (2.96, 10.03)	0.011^a
Age
<60	–				–		–
≥60	1.72 (1.11, 2.93)	0.290			1.56 (1.07, 2.67)	0.345
Sex
Female	–				–
Male	1.42 (1.02, 1.99)	0.284			1.28 (0.96, 1.85)	0.368
Tumor location
Transverse	–				–
Right	0.85 (0.55, 1.34)	0.523			0.81 (0.49, 1.28)	0.673
Left	1.16 (0.91, 1.66)	0.301			1.07 (0.85, 1.50)	0.455
pT status
T1/T2	–		–		–		–
T3/T4	2.60 (1.17, 4.36)	0.025^a	2.11 (1.01, 4.22)	0.036^a	2.28 (1.25, 4.64)	0.017^a	1.98 (1.12, 3.87)	0.024^a
pN status
Absent	–		–		–		–
Present	3.18 (2.03,7.67)	0.003^a	2.88 (1.21,4.70)	<0.001^a	3.03 (2.43, 7.07)	0.004^a	2.78 (1.27, 5.45)	0.011^a
pM status
Absent	–		–		–		–
Present	5.21 (2.42,10.61)	0.023^a	4.98 (2.33,9.75)	0.037^a	5.75 (2.21,10.87)	0.028^a	5.18 (2.08,9.15)	0.033^a
AJCC stage
I/II	–		–		–		–
III/IV	4.12 (2.37,8.86)	0.009^a	3.82 (1.55,6.71)	0.011^a	4.92 (2.49,9.19)	0.024^a	3.37 (1.43, 6.77)	0.031^a
Differentiation
Well	–		–		–		–
Moderate	3.59 (1.02, 6.12)	0.023^a	2.54 (1.35,4.71)	0.017^a	3.03 (1.25, 5.66)	0.008^a	2.69 (1.09, 4.96)	0.013^a
Poor	5.45 (2.22,12.34)	<0.001^a	4.76 (2.29,11.23)	0.004^a	5.75 (2.41,11.63)	0.019^a	5.08 (2.83, 10.21)	0.005^a

HR, hazard ratio; CI, confidence interval.

Statistically significant.