Table II.

Differentially expressed proteins in microRNA-148a inhibitor-transfected cells compared with control cells.

A, Upregulated differentially expressed proteins
Accession	Protein	Unused score	Coverage, %a	Peptide 95% CLa	iTRAQ ratea	P-valuea
sp|Q09666	AHNAK	457.84±0.62	66.71±1.69	352.5±12.02	4.57±0.18	<0.0001
sp|P02545	LMNA	91.37±2.67	66.04±3.30	75.5±3.54	9.83±0.77	<0.0001
tr|F5GZS6	SLC3A2	54.32±0.18	45.74±0.23	37.5±0.71	4.45±0.06	<0.0001
sp|O43707	ACTN4	130.18±3.61	71.84±4.11	167.5±7.78	2.54±0.80	<0.0001
sp|P35579	MYH9	222.67±10.28	59.18±2.38	319.5±9.19	1.65±0.05	<0.0001
tr|E7EPC6	CD44	20.93±1.51	15.41±0.38	14.5±0.71	5.85±0.19	<0.0001
sp|P16615-5	ATP2A2	48.62±5.43	30.59±3.83	32.5±0.71	2.10±0.18	<0.0001
sp|O43175	PHGDH	42.32±4.59	56.01±6.50	43.5±4.94	4.43±1.80	0.0004
sp|Q07065	CKAP4	37.42±3.34	37.13±0.12	23.5±2.12	1.84±0.07	0.0084
sp|P05556	ITGB1	34.97±1.27	25.50±0.27	22.5±3.54	2.35±0.33	0.0002
sp|Q9Y6N5	SQRDL	33.74±1.28	44.56±4.24	20.0±1.41	2.12±0.18	0.0007
sp|Q13501	SQSTM1	31.33±1.22	63.41±0.00	25.5±2.12	4.04±0.08	0.0002
sp|P07355-2	ANXA2	75.77±0.13	72.13±1.39	135.5±9.19	1.86±0.04	0.0012
sp|P21980	TGM2	46.15±2.05	45.30±6.38	30.0±2.83	2.12±0.28	0.0002
tr|H0Y323	CAPN2	49.09±2.84	48.01±5.43	34.5±3.54	2.39±1.14	0.0004
tr|F5H0Q5	AHSG	8.43±0.08	6.93±0.00	22.0±0.00	4.06±0.11	0.0014
sp|Q13751	LAMB3	14.62±2.70	11.48±1.39	8.5±0.71	3.12±0.45	0.0018
sp|Q96AG4	LRRC59	24.42±0.61	48.21±0.00	15.0±1.41	2.76±0.29	0.0006
sp|P37802	TAGLN2	48.05±5.01	75.88±0.71	76.5±0.71	4.01±1.16	0.0014
sp|O15231	ZNF185	6.63±0.86	10.45±1.44	3.5±0.71	3.60±0.05	0.0145
sp|P08670	VIM	78.14±2.44	69.52±0.30	128.5±2.12	6.78±0.66	0.0009
sp|P07203	GPX1	27.36±0.85	84.24±0.00	17.5±0.71	4.32±0.48	0.0013
sp|P46060	RANGAP1	44.64±3.22	53.24±0.12	28.5±0.71	1.66±0.02	0.0079
sp|O00159-2	MYO1C	51.34±4.12	34.29±0.48	30.5±4.95	3.26±1.68	0.0058
sp|P04083	ANXA1	52.37±6.22	68.64±1.02	91.5±9.19	1.84±0.17	0.0033
sp|Q92597	NDRG1	20.49±0.41	37.82±0.00	20.0±1.41	3.36±1.03	0.0019
tr|B4E0H8	ITGA3	23.64±2.69	16.20±2.59	16.5±3.54	2.09±0.54	0.0087
tr|E7ESU5	ALB	33.95±4.02	41.66±1.03	72.5±6.36	2.26±0.13	0.0023
tr|D6RAK8	GC	9.94±2.45	17.95±1.29	10.0±1.41	4.52±0.82	0.0036
tr|Q5T985	ITIH2	11.62±0.23	9.68±0.68	9.0±0.00	3.99±2.19	0.0080
sp|P26639	TARS	77.47±5.34	57.74±1.27	68.5±2.12	2.26±0.32	0.0040
sp|P49589-3	CARS	38.44±3.73	32.61±4.94	18.0±2.90	2.12±0.10	0.0176
tr|F5H7K4	NCEH1	17.57±0.62	26.90±0.79	10.5±0.71	2.25±0.61	0.0241
sp|P02788	LTF	8.71±1.27	9.86±0.00	12.5±0.71	7.29±0.62	0.0188
sp|Q92621	NUP205	33.73±1.67	12.23±2.81	20.5±3.54	2.33±0.29	0.0318
sp|Q9NZM1-6	MYOF	140.84±3.56	47.85±2.60	87.0±4.24	2.24±0.16	0.0062
sp|Q9Y2T3-3	GDA	39.77±1.44	59.45±0.00	38.0±1.41	3.18±0.40	0.0062
sp|P29317	EPHA2	15.51±5.52	11.99±2.03	10.0±1.41	3.46±0.34	0.0083
sp|P80723	BASP1	25.19±1.68	72.03±4.05	27.0±1.41	7.59±2.89	0.0101
sp|P48681	NES	23.27±1.01	10.73±0.87	12.5±0.71	2.86±0.11	0.0240
sp|P31947	SFN	20.68±0.27	67.34±1.71	37.0±1041	2.37±0.65	0.0190
sp|P16144-4	ITGB4	41.89±1.24	18.83±0.69	25.5±0.71	1.81±0.01	0.0364
sp|Q01995	TAGLN	6.56±2.14	25.13±3.88	5.0±1.41	2.31±0.35	0.0373
sp|Q6P9B6	KIAA1609	8.96±1.87	16.01±0.62	6.0±1.41	3.02±0.20	0.0326
B, Downregulated differentially expressed proteins
Accession	Protein	Unused scorea	Coverage, %a	Peptide 95% CLa	iTRAQ ratea	P-valuea
sp|A0MZ66	KIAA1598	50.71±0.09	51.74±0.78	31.0±2.12	0.58±0.04	0.0011
sp|O00232	PSMD12	35.44±1.51	47.03±2.02	24.0±2.83	0.47±0.04	0.0029
sp|O14818	PSMA7	29.16±1.11	62.70±0.28	23.0±2.83	0.47±0.09	0.0237
sp|O60749	SNX2	20.85±4.76	29.57±4.22	16.0±2.12	0.51±0.03	0.0015
sp|O75533	SF3B1	69±0.34	36.5±2.60	40.0±1.41	0.41±0.00	0.0014
sp|O95347	SMC–2	56.22±3.49	30.91±2.01	37.0±4.95	0.58±0.04	0.0068
sp|O95573	ACSL3	35.36±1.34	36.04±0.10	21.0±2.83	0.58±0.07	0.0096
sp|O95861	BPNT1	23.27±0.62	56.82±0.92	15.0±0.71	0.49±0.20	0.0206
sp|P00390	GSR	17.07±0.64	32.47±3.11	11.0±0.00	0.45±0.16	0.0018
sp|P00505	GOT2	53.15±1.19	66.62±0.16	39.0±4.24	0.53±0.02	0.0172
sp|P04040	CAT	34.55±2.03	48.29±2.81	22.0±0.71	0.49±0.01	0.0015
sp|P04075	ALDOA	97.5±2.79	87.23±1.36	212.0±7.07	0.50±0.02	0.0011
sp|P04792	HSPB1	41.05±1.21	79.51±8.28	53.0±1.41	0.23±0.23	0.0034
sp|P05455	SSB	41.26±0.87	51.10±1.21	26.0±1.41	0.49±0.03	0.0034
sp|P06744	GPI	51.08±0.08	55.19±1.52	65.0±4.24	0.41±0.10	0.0078
sp|P07195	LDHB	33.47±2.41	65.72±4.48	73.0±1.41	0.32±0.12	0.0161
sp|P07339	CTSD	33.9±0.68	50.85±4.98	36.0±2.12	0.54±0.04	0.0010
sp|P07942	LAMB1	42.6±3.96	18.47±1.27	27.0±3.54	0.54±0.06	0.0215
sp|P07954	FH	38.99±0.31	50.09±0.42	37.0±2.12	0.58±0.05	0.0065
sp|P09972	ALDOC	32.73±1.24	70.05±2.33	96.0±0.00	0.21±0.01	0.0020
sp|P11586	MTHFD1	76.09±4.05	50.16±4.99	53.0±3.54	0.60±0.04	0.0055
sp|P12004	PCNA	27.15±3.05	58.62±2.16	37.0±3.54	0.61±0.04	0.0032
sp|P13611-2	VCAN	25.2±1.73	8.053±0.53	17.0±0.71	0.37±0.12	0.0065
sp|P13797	PLS3	74.13±3.57	67.69±1.01	69.0±4.95	0.24±0.07	0.0037
sp|P21266	GSTM3	33.26±1.87	72.22±3.46	21.0±1.41	0.38±0.04	0.0050
sp|P23786	CPT2	27.57±5.16	33.06±5.06	17.0±3.54	0.61±0.04	0.0274
sp|P25789	PSMA4	27.86±0.86	65.13±1.63	32.0±4.95	0.58±0.00	0.0133
sp|P27824	CANX	57.96±1.73	62.92±3.71	53.0±0.71	0.31±0.10	0.0016
sp|P37268	FDFT1	17.91±0.20	32.85±2.71	12.0±2.12	0.30±0.10	0.0052
sp|P40937	RFC5	14.34±1.11	27.06±3.75	12.0±2.12	0.48±0.02	0.0278
sp|P42166	TMPO	48.96±6.58	57.28±2.55	35.0±3.54	0.28±0.04	0.0004
sp|P42704	LRPPRC	129.11±3.57	58.21±3.70	95.0±12.02	0.44±0.09	0.0003
sp|P48449	LSS	28.14±3.34	26.57±0.10	16.0±0.71	0.43±0.07	0.0314
sp|P48735	IDH2	36.91±0.72	44.02±4.38	21.0±0.71	0.49±0.07	0.0010
sp|P49321	NASP	50.23±3.21	55.08±2.87	38.0±2.12	0.29±0.00	0.0175
sp|P49327	FASN	200.88±9.07	56.81±0.37	167.0±3.54	0.21±0.01	<0.0001
sp|P49419	ALDH7A1	40.15±4.71	48.24±0	32.0±3.54	0.49±0.00	0.0238
sp|P51659	HSD17B4	48.92±2.98	50.87±0.86	36.0±4.95	0.47±0.06	0.0345
sp|P52209	PGD	60±8.37	66.97±9.81	54.0±4.24	0.48±0.11	0.0226
sp|P52943	CRIP2	16.69±0.41	44.47±2.38	12.0±1.41	0.58±0.11	0.0371

^aPresented as mean ± standard deviation. CL, confidence level; iTRAQ, isobaric tag for relative and absolute quantitation.