Table III.
Significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways associated with the identified differentially expressed proteins.
| Pathway | Count | P-value | Associated genes |
|---|---|---|---|
| Arrhythmogenic right ventricular cardiomyopathy | 6 | 0.0007 | ATP2A2, ACTN4, LMNA, ITGB4, ITGA3, ITGB1 |
| ECM-receptor interaction | 6 | 0.0012 | LAMB3, CD44, ITGB4, ITGA3, LAMB1, ITGB1 |
| Glutathione metabolism | 5 | 0.0013 | GSR, GPX1, GSTM3, PGD, IDH2 |
| Pentose phosphate pathway | 4 | 0.0017 | ALDOA, GPI, ALDOC, PGD |
| Glycolysis/Gluconeogenesis | 5 | 0.0025 | ALDOA, GPI, LDHB, ALDH7A1, ALDOC |
| Hypertrophic cardiomyopathy (HCM) | 5 | 0.0087 | ATP2A2, LMNA, ITGB4, ITGA3, ITGB1 |
| Dilated cardiomyopathy | 5 | 0.0114 | ATP2A2, LMNA, ITGB4, ITGA3, ITGB1 |
| Focal adhesion | 7 | 0.0120 | LAMB3, ACTN4, ITGB4, ITGA3, LAMB1, CAPN2, ITGB1 |
| Small cell lung cancer | 4 | 0.0465 | LAMB3, ITGA3, LAMB1, ITGB1 |
ATP2A2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; ACTN4, α-actin 4; LMNA, lamin A/C; ITGB4, integrin subunit β4; ITGA3, integrin subunit α3; ITGB1, integrin subunit β1; LAMB3, laminin subunit β3; CD44, cluster of differentiation 44; LAMB1, laminin subunit β1; GSR, glutathione-disulfide reductase; GPX1, glutathione peroxidase 1; GSTM3, glutathione S-transferase µ3; PGD, phosphogluconate dehydrogenase; IDH2, isocitrate dehydrogenase (NADP+) 2; ALDOA, aldolase, fructose-bisphosphonate A; GPI, glucose-6-phophate isomerase; ALDOC, aldolase, fructose-bisphosphonate C; ALDH7A1, aldehyde dehydrogenase 7 family member A1; CAPN2, caplain 2.