Growth inhibition of MM cells by pomalidomide, 1 µM pomalidomide plus dexamethasone, and afuresertib. (A-C) The growth inhibitory effect of three therapies (pomalidomide; 1 µM pomalidomide plus dexamethasone; and afuresertib) after treatment for 72 h in MM cells. The data represent the mean of three independent experiments. (D and E) Growth inhibitory effect of low-dose AFU treatment in combination with a suboptimal dose of pomalidomide (1 µM) or lenalidomide (1 µM) with dexamethasone on two MM cell lines. *Represents statistically significant (P<0.05), calculated by post hoc Tukey test. LD, lenalidomide plus dexamethasone; AFU, afuresertib; POM, pomalidomide; DEX, dexamethasone.