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. 2018 Apr 10;15(6):8735–8743. doi: 10.3892/ol.2018.8447

Figure 2.

Figure 2.

BSO induces ferroptosis in cancer cells. (A) Rescue effects of ferrostatin-1 against BSO-induced decrease of cell viability in PANC-1 cell lines; ***P<0.0005 using Williams' test. (B) Effects of FAC on viability reduction by BSO in PANC-1 cells, compared by two-way ANOVA: BSO and FAC interaction, P<0.001, F=69.56; BSO, P<0.001, F=266.89; FAC, P<0.001, F=312.01; Tukey's post hoc test, **P<0.01 and ***P<0.001. (C) Effects of FAC on viability reduction by BSO in HT-29, compared by two-way ANOVA: BSO and FAC interaction, P<0.001, F=157.96; BSO, P<0.001, F=179.84; FAC, P<0.001, F=287.57; Tukey's post hoc test, ***P<0.001. Effects of (D) NAC and (E) ferrostatin-1 on cell viability reduction by BSO in SW48 cells; **P<0.005 and ***P<0.0005 using Williams' test. Data are presented as the mean ± standard deviation (n=3). BSO, buthionine sulfoximine; FAC, ferric ammonium citrate; ANOVA, analysis of variance; NAC, N-acetylcysteine.