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. 2018 Apr 27;15(6):9917–9922. doi: 10.3892/ol.2018.8596

Figure 2.

Figure 2.

Transwell assay reveals that cell migration is inhibited by 53BP1 overexpression. (A) Representative image of migratory SKOV3/pLPC-53BP1 cells (magnification, ×10). (B) Representative image of migratory SKOV3/pLPC-vector cells (magnification, ×10). (C) Compared with migratory SKOV3/pLPC-vector cells, the mean number of migratory SKOV3/pLPC-53BP1 cells was decreased from 230±58 to 45±12 (P<0.05). (D) MMP-9 and MMP-2 activity were assessed using gelatin zymography. (E) Compared with that in SKOV3/pLPC-vector cells, the protein expression of MMP-9 in SKOV3/pLPC-53BP1 cells was significantly inhibited and (F) the protein expression of MMP-2 was not significantly altered. Data were represented as the mean ± standard deviation. *P<0.05 vs. control. 53BP1, tumor protein p53 binding protein 1; MMP, matrix metalloproteinase.