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MuvB contributes to gene regulation throughout the cell cycle. MuvB binds p130/p107 and E2F4-DP1 in G0/G1 to form the DREAM complex and repress both early and late cell cycle genes. Upon cell cycle re-entry and during the S phase, MuvB binds B-Myb, forming MMB for expression of early cell cycle genes. The interaction between B-Myb and MuvB is important for recruiting FoxM1 for late cell cycle gene expression and subsequent mitosis.
