Fig.2.

Hypothetical model illustrating the links between the main AD biomarkers and the underlying neuropathological processes. In this multidetermined perspective of the disease, Aβ and tau pathologies appear as at least partly independent processes, under the influence of genetic and environmental factors, and interact to lead to AD disease. Other neuropathological processes, some of which are still unknown, are likely also involved in the physiopathology of the disease. Adapted from [21, 22].