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Schematic representation of the graded effect of APOE4 on structural MRI (atrophy), FDG-PET (metabolism), and molecular (Aβ deposition) cortical changes. APOE4 effects clearly predominate on Aβ deposition (thick arrows), while the effects are more modest on cortical metabolism and volume (thin arrows). This figure also illustrates that APOE4 operates through both Aβ-dependent and Aβ-independent processes. From [31].
