Fig. 2.

Administration with the tocotrienol-rich fraction (TRF) of palm oil improves exploration activity in AβPP/PS1 mice as measured by the open field test. A, B) Tg-ctrl mice displayed significantly lower total rearing time and number of rearings compared to WT-ctrl mice, while Tg-TRF mice showed a significant improvement in total rearing time and a slight increase in rearing frequency. C, D) The time spent in the field center and the frequencies of central entries were slightly higher in both WT-ctrl and Tg-TRF mice compared to Tg-ctrl mice, although the difference was not significant. Data represent mean±S.E.M. [Bonferroni post hoc test after analysis of variance (WT-ctrl, n = 12; Tg-ctrl, n = 8; Tg-TRF; n = 9; Tg-PO, n = 9)]. ^**p < 0.01, ^*p < 0.05.