Table 1.
Region Model | Hippocampus | mPFC | Striatum | |||||
WT-ctrl: Tg-ctrl | Tg-ctrl: Tg-TRF | WT-ctrl: Tg-ctrl | Tg-ctrl: Tg-TRF | WT-ctrl: Tg-ctrl | Tg-ctrl: Tg-TRF | |||
PCA | ESI (+) | |||||||
A | 2 | 4 | 2 | 4 | 4 | 4 | ||
R2X(cum) | 0.724 | 0.989 | 0.706 | 0.976 | 0.970 | 0.962 | ||
Q2 (cum) | 0.235 | 0.876 | 0.091 | 0.811 | 0.708 | 0.719 | ||
ESI (–) | ||||||||
A | 4 | 4 | 3 | 3 | 4 | 3 | ||
R2X(cum) | 0.985 | 0.972 | 0.873 | 0.952 | 0.945 | 0.733 | ||
Q2 (cum) | 0.879 | 0.797 | 0.205 | 0.312 | 0.538 | 0.338 | ||
OPLS-DA | ESI (+) | |||||||
A | 1+3 | 1+1 | 1+3 | 1+3 | 1+3 | 1+2 | ||
R2X(cum) | 0.918 | 0.802 | 0.898 | 0.906 | 0.969 | 0.859 | ||
R2Y(cum) | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | ||
Q2 (cum) | 0.994 | 0.997 | 0.950 | 0.992 | 0.999 | 0.985 | ||
p (CV-ANOVA) | 0.05 | 0.004 | 0.05 | 0.05 | 0.05 | 0.185 | ||
ESI (–) | ||||||||
A | 1+3 | 1+1 | 1+3 | 1+3 | 1+3 | 1+3 | ||
R2X(cum) | 0.978 | 0.787 | 0.934 | 0.951 | 0.932 | 0.937 | ||
R2Y(cum) | 0.998 | 0.996 | 1.000 | 1.000 | 1.000 | 1.000 | ||
Q2 (cum) | 0.969 | 0.942 | 0.931 | 0.962 | 0.999 | 0.984 | ||
p (CV-ANOVA) | 0.05 | 0.086 | 0.05 | 0.05 | 0.05 | 0.05 |
A: component (first component for PCA and first component plus orthogonal component for OPLS-DA); R2X(cum): total amount of the variation of the X variables explained by the model; R2Y(cum): total amount of the variation of the Y variables explained by the model; Q2 (cum): total amount of the predictability of the model.