. 2018 May 8;63(3):989–1002. doi: 10.3233/JAD-180059

Table 3.

Pre- and postoperative features in patients with iNPH

	Low-pTau						High-pTau						Low-pTau versus High-pTau
	Baseline (B)	1 year after (1 y)	2 years after (2 y)	p-value			Baseline (B)	1 year after (1 y)	2 years after (2 y)	p-value			p-value
				B versus 1 y	B versus 2 y	1 versus 2 y				B versus 1 y	B versus 2 y	1 versus 2 y	B	1y	2y
Neuropsychological test: median [min-max]
MMSE	23 [15–29]	26 [18–29]	25 [17–30]	**0.001	0.079	0.104	22 [16–28]	24 [10–27]	20 [0–22]	0.893	**0.007	**0.005	0.698	0.052	**0.001
FAB	11.5 [4–17]	12 [7–18]	12.5 [6–17]	**0.005	*0.039	0.284	9 [4–15]	11 [3–16]	11 [3–15]	0.944	0.943	0.783	0.404	0.139	0.247
Clinical findings: median [min-max]
mRS	3 [1–4]	3 [1–4]	2 [1–4]	*0.017	**0.001	0.285	3 [2–4]	2 [1–4]	3 [1–4]	0.157	0.608	*0.038	0.555	0.445	0.063
INPHGS
Gait disturbance	2 [1–4]	2 [0–3]	2 [0–3]	***<0.001	***<0.001	0.166	2 [2–3]	2 [1–4]	3 [1–4]	0.480	0.739	0.083	0.655	0.879	0.163
Dementia	2 [0–3]	1 [0–3]	1 [0–3]	**0.005	**0.003	1.000	2 [1–3]	2 [1–4]	3 [1–4]	0.414	0.305	0.058	0.608	0.219	**0.006
Urinary incontinence	2 [0–3]	1 [0–3]	1 [0–3]	** 0.001	**0.003	0.193	2 [1–3]	1 [1–4]	2 [1–4]	0.550	0.319	*0.023	0.937	0.496	**0.002
Biomarkers: mean ± SD	Baseline (B)	1 year after (1 y)	1 y/B	B versus 1 y			Baseline (B)	1 year after (1 y)	1 y/B	B versus 1 y			Low- versus High-pTau (B)	Low- versus High-pTau (B)
pTau (pg/ml)	20.1 ± 4.7	55.0 ± 29.7	2.73	***<0.001			39.4 ± 8.9	93.6 ± 53.2	2.38	*0.019			***<0.001	*0.037
Aβ₄₂ (pg/ml)	487.1 ± 227.6	786.2 ± 265.7	1.61	***<0.001			496.8 ± 300.3	507.6 ± 348.6	1.02	0.534			0.735	*0.014
Aβ₄₂ toxic conformer (pg/ml)	53.4 ± 18.2	69.7 ± 17.0	1.31	***<0.001			62.3 ± 18.4	66.6 ± 26.4	1.12	0.423			0.203	0.252
Aβ₄₂ toxic conformer ratio (%)	13.3 ± 9.4	10.3 ± 5.5	0.77	0.116			15.2 ± 7.3	15.7 ± 6.1	1.03	0.107			0.770	**0.002

Results are shown as the median [minimum-maximum] or mean ± SD. Mann-Whitney U tests were used to compare low-pTau versus high-pTau groups and Wilcoxon signed-rank tests were used for all other comparisons. *p < 0.05, **p < 0.01, and ***p < 0.001 were considered to be statistically significant. MMSE, Mini-Mental State Examination; FAB, frontal assessment battery; mRS, modified Rankin scale; INPHGS, iNPH grading scale.