Fig. 3. Platinum distribution in mouse kidney upon treatment with compound 1. NanoSIMS 12C14N−, 31P−, 34S−, and 195Pt− secondary ion signal intensity distribution images show the subcellular platinum localization in a semi-thin section of a murine kidney cortex. Colored regions of interest (ROI) refer to glomerulus (magenta), proximal convoluted tubule cells (cyan), mesangial cells (green), and capillaries (red). Arrows show platinum hotspots co-localized with sulfur-rich cytoplasmic organelles in podocytes and cells of the tubule. Intensities are displayed on a false color scale, ranging from low intensities (black) to high intensities (red/white). Scale bars = 5 μm.
