Table 1.

Combination index (CI) and dose reduction index (DRI) values for temozolomide (TMZ) and Trifolium pretense extract combination

Temozolomide (μM)	Extract (μg/ml)	Fa	CI value	DRI Temozolomide	DRI extract
150	25	0.52	0.42	4.92	4.49
300	50	0.61	0.46	5.62	3.45
600	100	0.78	0.27	17.65	4.50
1200	200	0.81	0.43	13.35	2.79
2400	400	0.90	0.30	37.91	3.55

Fa; Fraction affected.