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. 2018 May 28;20(3):435–442. doi: 10.22074/cellj.2018.5213

Table 2.

Top 5 hub nodes in the up- and downregulated protein-protein interaction (PPI) network


Gene Up/down Degree

MAPK14 Up 28
STAT3 Up 27
MAPK3 Up 26
GRB2 Up 22
SYK Up 21
LCK Down 29
FYN Down 25
PLCG1 Down 18
PIK3R1 Down 17
CD247 Down 16