Table 1.
Pharmacokinetic parameters of Radotinib HCl and Nilotinib in plasma and brain tissue
| Animal no. | Radotinib HCl |
Nilotinib |
||||||
|---|---|---|---|---|---|---|---|---|
| Plasma |
Brain tissue |
Plasma |
Brain tissue |
|||||
| AUCt (ng·h/ml) | Cmax (ng/ml) | AUCt (ng·h/ml) | Cmax (ng/ml) | AUCt (ng·h/ml) | Cmax (ng/ml) | AUCt (ng·h/ml) | Cmax (ng/ml) | |
| 1 | 62 294.7 | 9 680.1 | 591.3 | 70.7 | 87 985.3 | 18 157.3 | 164.0 | 34.4 |
| 2 | 74 356.2 | 11 135.4 | 576.5 | 101.5 | 77 472.1 | 16 878.9 | 155.7 | 35.5 |
| 3 | 124 593.5 | 9 433.2 | 772.4 | 61.5 | 175 949.6 | 24 529.6 | 272.5 | 38.0 |
| Mean | 87 081.4 | 10 082.9 | 646.7 | 77.9 | 11 3802.3 | 19 855.2 | 197.4 | 35.9 |
| SD | 33 041.4 | 919.8 | 109.1 | 21.0 | 54 077.2 | 4 098.3 | 65.1 | 1.9 |