FIGURE 6.
Risk factors and aneurysmal wall composition. Spearman correlation between intracranial aneurysm (IA) size and CD68 (A), total collagen (B), and type III collagen (C) contents in UR-IAs. UR-IAs with a rough appearance have a higher content of type III collagen (D) and a lower type I collagen-type III collagen ratio (E) than UR-IA with a smooth appearance (n = 15 and 14, respectively, *p < 0.05, nonparametric Mann-Whitney U test). SMC content is lower in the unruptured aneurysmal wall of smokers (current and former) in comparison to nonsmokers (F, n = 17 for R-IA, n = 21 for UR-IA/smokers, and n = 10 for UR-IA/nonsmokers, *p < 0.05, ***p < 0.001, nonparametric Mann-Whitney U test).