Figure 1.

STAT1–STAT4 variants show a genome-wide association in a multi-ethnic discovery cohort. Each variant is represented as a data point in the context of its genomic location and is colored on the basis of linkage disequilibrium with the most associated variant in each individual ancestral analysis (A, European & European American; B, Asian & Asian American; C, Amerindian; D, African American). Genomic position is provided using GRCh37 (hg19) coordinates. The variants were assessed in a logistic regression model using the admixture estimates as a covariate. Genome-wide significance was defined as P < 5 × 10⁻⁸.