Table 1.

ESCMID grading system of strength of recommendation and quality of evidence [1]

Strength of recommendation
A	Strongly support a recommendation for use
B	Moderately support a recommendation for use
C	Marginally support a recommendation for use
D	Support a recommendation against use
Quality of evidence
I	Evidence from at least one properly designed randomized, controlled trial
II*	Evidence from at least one well-designed clinical trial, without randomization; from cohort- or case-control analytic studies (preferably from more than one center); from multiple time series; or from dramatic results from uncontrolled experiments
III	Evidence from opinion of respected authorities, based on clinical experience, descriptive case studies, or report of expert committees
*Added index
r	Meta-analysis or systematic review of randomized controlled trials
t	Transferred evidence, i.e. results from different patients’ cohorts or similar immune status situation
h	Comparator group is a historical control
u	Uncontrolled trial
a	Abstract published at an international meeting