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. Author manuscript; available in PMC: 2019 Jan 10.
Published in final edited form as: Cell Host Microbe. 2017 Dec 21;23(1):41–53.e4. doi: 10.1016/j.chom.2017.11.003

Figure 4. Microbiota ablation eliminated inulin’s beneficial effects in HFD-induced metabolic syndrome.

Figure 4

C57BL/6 male mice (n=10) were fed HFD supplemented with cellulose (HFD-200 Cell) or inulin (HFD-200 Inul) with or without antibiotic cocktail in drink water. A) Body mass over time, B) Colon length, C) Colon weight, D) Epididymal fat and mesenteric fat were measured at the end of experiment. E–G). Glucose tolerance was measured and area under curve (AUC) calculated. H) 5 h fasting glucose. I) Mice were fasted 5 h and intraperitoneally injected with insulin to measure insulin sensitivity. J) Correlation between 5 h fasting glucose and colon weight using data from Figure 1&4. Data were expressed as mean ± SEM. Statistical significance was assessed by unpaired Student t test. *p<0.05; **p<0.01; n.s, not significance. See also Figure S4.