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. Author manuscript; available in PMC: 2018 Jun 18.
Published in final edited form as: Leukemia. 2017 Aug 14;32(1):203–213. doi: 10.1038/leu.2017.250

Figure 1. SHP2 is required for BCR-ABL1-evoked myeloid transformation and initiation of CML-like MPN.

Figure 1

(a) Cytokine-independent colony formation of WT or Ptpn11fl/fl cells infected with pMIGR1 (GFP), p210MIGFP (BCR-ABL), or p210MIGFPCre (BCR-ABL-GFPCre) virus (n = 4). (n.s.=not significant; *** P < 0.001). WT cells infected with p210MIGFP yielded more cytokine-independent colonies than infected with p210MIGFPCre (P < 0.001). (b) Kaplan-Meier curve of recipients of WT or Ptpn11fl/fl donor cells infected with p210MIGFPCre virus (right, n = 13). Recipients of the Ptpn11fl/fl donor cells survived significantly longer (P = 0.004; log-rank test). A similar trend showing that p210GFPCre recipients survive longer than p210GFP recipients was reported by Walz et al..43