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. Author manuscript; available in PMC: 2018 Jun 18.
Published in final edited form as: Leukemia. 2017 Aug 14;32(1):203–213. doi: 10.1038/leu.2017.250

Figure 2. SHP2 is required for CML maintenance.

Figure 2

(a) Kaplan-Meier curve for recipients of MxCre (Mx) or MxCre;Ptpn11fl/fl (Mx-fl/fl) bone marrow infected with p210MIGFP virus, with (n = 10) or without (n = 5) poly I:C induction. The Mx-fl/fl + poly I:C group survived significantly longer than the other groups (P = 0.004; log-rank test). (b) GFP+Lin−Sca1+cKit+ splenocytes were isolated from poly I:C-induced recipients of Mx or Mx-fl/fl donor cells, and stained with Annexin V and Sytox blue (n = 4). Note that apoptosis is significantly higher in the Mx-fl/fl group than in Mx mice (P < 0.01). (c) Representative immunoblots of poly I:C-induced Mx or Mx-fl/fl BCR-ABL1+ myeloid cell lysates. Similar results were obtained in ≥5 biological replicates.