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. Author manuscript; available in PMC: 2018 Jun 18.
Published in final edited form as: J Alzheimers Dis Parkinsonism. 2018 Jan 9;8(1):412.

Figure 3. Intrinsic and circuit heterogeneity of CA1 across anatomical axes.

Figure 3

A Longitudinal axis intrinsic differences include differential expression of physiologically relevant genes (italics) and increased electrical excitability in ventral CA1. Circuit differences derive from increased diversity of axonal projections in ventral CA1 (below), mainly from deep (blue triangle) rather than superficial neurons (black triangle). Targets include EC, prefrontal cortex (PFC), amygdala (AMG), olfactory areas (OLF), and nucleus accumbens (NAC). Dorsal CA1 neurons (top) project back to EC. B. Transverse and radial axis molecular differences are few (italics). Circuit differences derive from preferential targeting of proximal CA1 by medial entorhinal cortex (MEC) and distal CA1 by lateral entorhinal cortex (LEC). Moreover, MEC favors deep and LEC favors superficial neurons. Deep neurons also receive more proximal inhibition, partially via superficial neurons. CA2 preferentially excites deep neurons. Variability of inhibition to the basal dendrite is not known (not shown).