Skip to main content
. Author manuscript; available in PMC: 2018 Jun 18.
Published in final edited form as: J Alzheimers Dis Parkinsonism. 2018 Jan 9;8(1):412.

Figure 5. Spatiotemporal evolution of Alzheimer disease across human CA1 axes.

Figure 5

A Biomarkers of Alzheimer disease (AD) begin anteriorly in the hippocampal head and progress posteriorly towards the hippocampal tail. B. Left, expansion of the coronal cross-section indicated in A. showing position of the hippocampus in the temporal lobe (gray square). Right, detailed view of human hippocampus indicating that AD pathology begins in distal CA1 at the CA1-S border, and progresses proximally to CA2. Distribution across the radial axis is unknown.