Table 1. ACKR3 Ligand Interactions in Physiology a.
| Ligand | Cardiovascular Physiology | Neurobiology | Renal Physiology | Reproductive Physiology | Virology/Immunology |
|---|---|---|---|---|---|
| CXCL12 CXCL11 | May improve cardiac function by controlling CXCL12 concentrations [56] n.d. | Induces MAPK activation in cortical neurons [70]. Modulates CXCL12 in astrocytes and Schwann cells [67, 71] n.d. | Renal development [75] and carcinoma [77, 78] n.d. | Supports testicular development [104] n.d. | n.d. Inflammatory chemokine [38] |
| AM | Titrates AM during cardiovascular development [12] | n.d. | n.d. | n.d. | n.d. |
| vCCL2 | n.d. | n.d. | n.d. | n.d. | KSHV [39] |
| Pro-enkephalin A | n.d. | Circadian glucocorticoid oscillation, behavior [50] | n.d. | n.d. | n.d. |
a
References are provided as brackets in table
b
not determined, n.d.