Table 2. Changes in Body Weight, Body Composition, and Glucose Metabolic Parameters.
| Dapagliflozin (n = 28) |
P value | Non-SGLT2i (n = 22) |
P value | |||
|---|---|---|---|---|---|---|
| Baseline | 6 months | Baseline | 6 months | |||
| HbA1c (%) | 7.9 (7.3–8.7) | 6.8 (6.4–7.5) | p < 0.01 | 7.6 (7.2–8.1) | 7.0 (6.6–7.7) | p < 0.01 |
| Absolute change (%) | −1.2 (−1.4−−0.5) | −0.6 (−1.0−−0.3) | ||||
| Fasting plasma glucose (mg/dl) | 137 ± 38 | 116 ± 24 | p < 0.01 | 139 ± 35 | 127 ± 27 | p < 0.18 |
| Absolute change (mg/dl) | −20.5 ± 27.3 | −12.4 ± 42.0 | ||||
| Body mass index (kg/m2) | 27.5 ± 2.4 | 26.3 ± 2.5 | p < 0.01 | 26.2 ± 3.4 | 25.8 ± 3.6 | p < 0.03 |
| Absolute change (kg/m2) | −1.2 ± 0.9 | † | −0.4 ± 0.8 | |||
| Body weight (kg) | 76.7 ± 7.4 | 73.3 ± 7.5 | p < 0.01 | 71.6 ± 10.3 | 70.6 ± 10.8 | p < 0.03 |
| Absolute change (kg) | −3.4 ± 2.6 | † | −1.1 ± 2.0 | |||
| Waist circumference (cm) | 96.7 ± 6.6‡ | 92.9 ± 7.4 | p < 0.01 | 92.5 ± 7.4 | 91.0 ± 8.2 | p < 0.06 |
| Absolute change (cm) | −2.8 (−6.6−−0.8) | −1.3 (−3.7−1.7) | ||||
| Total Fat mass (kg) | 24.9 ± 6.0‡ | 21.8 ± 6.6 | p < 0.01 | 21.3 ± 6.1 | 20.7 ± 6.8 | p < 0.20 |
| Absolute change (kg) | −3.1 ± 2.6 | † | −0.6 ± 2.0 | |||
| Body Fat Percentage (%) | 32.3 ± 7.3 | 29.6 ± 8.2 | p < 0.01 | 29.6 ± 7.4 | 29.0 ± 8.0 | p < 0.26 |
| Absolute change (%) | −2.7 ± 2.9 | † | −0.5 ± 2.2 | |||
| Soft lean mass (kg) | 49.1 ± 6.3 | 48.6 ± 6.8 | p = 0.18 | 47.6 ± 7.9 | 47.1 ± 7.8 | p = 0.12 |
| Absolute change (kg) | −0.5 ± 1.8 | −0.5 ± 1.3 | ||||
| Soft lean mass percentage (%) | 64.1 ± 6.8 | 66.4 ± 7.8 | p < 0.01 | 66.6 ± 7.1 | 67.1 ± 7.6 | p < 0.25 |
| Absolute change (%) | 2.4 ± 2.6 | † | 0.5 ± 2.1 | |||
| Skeletal muscle mass (kg) | 28.7 ± 4.0 | 28.5 ± 4.3 | p = 0.34 | 27.8 ± 5.0 | 27.5 ± 4.9 | p = 0.15 |
| Absolute change (kg) | −0.2 ± 1.2 | −0.2 ± 0.7 | ||||
| Skeletal muscle mass percentage (%) | 37.5 ± 4.3 | 38.9 ± 5.0 | p < 0.01 | 38.8 ± 4.4 | 39.2 ± 4.7 | p < 0.18 |
| Absolute change (%) | 1.5 ± 1.7 | ‡ | 0.4 ± 1.2 | |||
| Psoas muscle area Index (cm2/m2) | 6.46 ± 1.82 | 6.39 ± 1.80 | p = 0.13 | 6.56 ± 1.92 | 6.48 ± 1.88 | p = 0.10 |
| Absolute change (cm2/m2) | −0.071 (−0.214−0.087) | 0.000 (−0.121−0.000) | ||||
| Paraspinal muscle attenuation (HU) | 43.6 (38.7–48.5) | 45.1 (38.9–50.6) | p < 0.01 | 43.6 (39.6–46.9) | 43.1 (37.5–47.7) | p < 0.86 |
| Absolute change (HU) | 1.61 ± 2.32 | ‡ | 0.10 ± 2.3 | |||
HbA1c, hemoglobin A1c,
†
p < 0.01,
‡
p < 0.05 Dapagliflozin group versus Non-SGLT2 inhibitor group at baseline and absolute change