Table S1.
List of serum proteins between type 1 diabetes patients and healthy controls as identified by LC–MSE analysis
| Accession number | Protein name | Molecular weight | Matched peptides | Coverage (%) | Score |
|---|---|---|---|---|---|
| P43652 | Afamin | 69,069 | 4/61 | 11.52 | 100.66 |
| P02763 | Alpha-1-acid glycoprotein 1 | 23,512 | 9/17 | 53.73 | 11,680.58 |
| P19652 | Alpha-1-acid glycoprotein 2 | 23,603 | 8/19 | 39.80 | 8,975.25 |
| P01011 | Alpha-1-antichymotrypsin | 47,651 | 16/31 | 45.63 | 4,340.51 |
| P01009 | Alpha-1-antitrypsin | 46,737 | 34/35 | 62.44 | 13,832.54 |
| P04217 | Alpha-1B-glycoprotein | 54,254 | 8/26 | 51.31 | 6,138.02 |
| P08697 | Alpha-2-antiplasmin | 54,566 | 7/34 | 25.46 | 694.29 |
| P02765 | Alpha-2-HS glycoprotein | 39,325 | 4/18 | 50.68 | 2,842.23 |
| P01023 | Alpha-2-macroglobulin | 163,291 | 66/95 | 69.54 | 11,454.35 |
| P01019 | Angiotensinogen | 53,154 | 12/25 | 35.26 | 4,547.05 |
| Q9UJ72 | Annexin A10 | 37,278 | 4/35 | 10.19 | 134.28 |
| P02647 | Apolipoprotein A I | 30,778 | 27/32 | 68.54 | 29,954.64 |
| P02652 | Apolipoprotein A II | 11,175 | 6/11 | 72.00 | 9,656.85 |
| P06727 | Apolipoprotein A IV | 45,399 | 12/42 | 54.55 | 2,142.37 |
| P02656 | Apolipoprotein C III | 10,852 | 3/10 | 36.36 | 12,643.42 |
| P05090 | Apolipoprotein D | 21,276 | 7/12 | 30.69 | 1,265.36 |
| P02649 | Apolipoprotein E | 36,154 | 6/30 | 20.19 | 350.88 |
| P02749 | Beta 2 glycoprotein 1 | 38,298 | 14/22 | 62.03 | 4,930.08 |
| Q9Y5Z0 | Beta secretase 2 | 56,181 | 3/23 | 9.46 | 140.23 |
| P22792 | Carboxy peptidase N subunit 2 | 60,557 | 5/30 | 13.03 | 334.61 |
| O43866 | CD5 antigen like | 38,088 | 8/31 | 43.80 | 614.25 |
| Q7L2Z9 | Centromere protein Q | 30,595 | 4/28 | 17.16 | 121.48 |
| O43303 | Centriolar coiled coil protein of 110 kDa | 113,424 | 9/80 | 10.67 | 226.74 |
| P00450 | Ceruloplasmin | 122,205 | 27/80 | 57.28 | 3,369.44 |
| P10909 | Clusterin | 52,495 | 12/36 | 32.96 | 3,176.77 |
| P00748 | Coagulation factor XII | 67,792 | 4/40 | 5.37 | 96.90 |
| P13671 | Complement component C6 | 104,787 | 10/65 | 9.31 | 159.79 |
| P01024 | Complement C3 | 187,149 | 61/136 | 51.41 | 8,628.71 |
| P0C0L4 | Complement C4 A | 192,785 | 52/118 | 54.59 | 5,352.24 |
| P0C0L5 | Complement C4 B | 192,752 | 44/117 | 48.57 | 5,333.65 |
| P00751 | Complement factor B | 85,533 | 23/64 | 38.09 | 1,924.60 |
| P08603 | Complement factor H | 139,097 | 33/96 | 40.70 | 1,155.49 |
| P05156 | Complement factor I | 65,751 | 2/42 | 5.49 | 117.71 |
| P08185 | Corticosteroid binding globulin | 45,141 | 6/23 | 27.90 | 371.10 |
| P04003 | C4b binding protein alpha chain | 67,033 | 13/45 | 30.82 | 1,198.61 |
| A6NLW8 | Double homeobox protein A | 23,817 | 1/21 | 13.24 | 142.05 |
| O43543 | DNA repair protein XRCC2 | 31,957 | 2/19 | 10.36 | 182.94 |
| Q9NPG1 | Frizzled 3 | 76,263 | 2/54 | 6.16 | 148.64 |
| P06396 | Gelsolin | 85,968 | 17/51 | 32.86 | 661.02 |
| Q969I3 | Glycine N-acyltransferase like protein1 | 35,101 | 3/17 | 11.26 | 149.87 |
| Q13588 | GRB2 related adapter protein | 25,337 | 2/20 | 26.27 | 389.12 |
| O96020 | G1 S specific cyclin E2 | 46,757 | 4/29 | 11.88 | 105.55 |
| P00738 | Haptoglobin | 45,205 | 27/28 | 70.94 | 17,966.31 |
| P00739 | Haptoglobin related protein | 3,903 | 20/25 | 46.26 | 7,405.70 |
| P69905 | Hemoglobin subunit alpha | 15,256 | 6/9 | 76.76 | 3,268.27 |
| P68871 | Hemoglobin subunit beta | 15,998 | 7/13 | 57.82 | 4,909.04 |
| P02042 | Hemoglobin subunit delta | 16,056 | 5/13 | 29.25 | 4,275.18 |
| P02100 | Hemoglobin subunit epsilon | 16,203 | 2/14 | 21.77 | 4,275.18 |
| P69891 | Hemoglobin subunit gamma 1 | 16,140 | 5/13 | 40.82 | 4,306.96 |
| P69892 | Hemoglobin subunit gamma 2 | 16,126 | 4/13 | 38.10 | 4,295.91 |
| P02790 | Hemopexin | 51,677 | 21/34 | 50.87 | 16,740.46 |
| P05546 | Heparin cofactor 2 | 57,071 | 7/36 | 11.62 | 295.97 |
| P04196 | Histidine rich glycoprotein | 59,578 | 12/33 | 24.95 | 1,886.61 |
| P17482 | Homeobox protein Hox B9 | 28,059 | 1/23 | 15.20 | 155.80 |
| P01876 | Ig alpha-1-chain C region | 37,655 | 20/23 | 67.42 | 19,361.04 |
| P01877 | Ig alpha-2-chain C region | 36,526 | 15/22 | 69.41 | 11,700.44 |
| P01857 | Ig gamma 1 chain C region | 36,106 | 9/21 | 37.58 | 1,570.00 |
| P01859 | Ig gamma 2 chain C region | 35,901 | 4/20 | 17.18 | 300.21 |
| P01860 | Ig gamma 3 chain C region | 41,287 | 4/24 | 12.20 | 702.83 |
| P01861 | Ig gamma 4 chain C region | 35,941 | 7/20 | 33.94 | 1,236.51 |
| P01766 | Ig heavy chain VIII region BRO | 13,227 | 4/6 | 40.83 | 4,324.36 |
| P01767 | Ig heavy chain VIII region BUT | 11,906 | 1/8 | 9.57 | 976.53 |
| P01774 | Ig heavy chain VIII region POM | 12,710 | 1/8 | 15.97 | 2,043.78 |
| P01777 | Ig heavy chain VIII region TEI | 12,559 | 2/6 | 36.13 | 4,324.36 |
| P01765 | Ig heavy chain VIII region TIL | 11,612 | 2/6 | 33.04 | 2,043.78 |
| P01779 | Ig heavy chain VIII region TUR | 12,188 | 1/7 | 16.38 | 2,043.78 |
| P01776 | Ig heavy chain VIII region WAS | 12,847 | 2/7 | 29.91 | 2,043.78 |
| P01763 | Ig heavy chain VIII region WEA | 12,142 | 1/6 | 9.65 | 976.53 |
| P01764 | Ig heavy chain VIII region 23 | 12,582 | 2/8 | 18.80 | 965.64 |
| P01871 | Ig mu chain C region | 49,307 | 25/38 | 63.94 | 8,892.79 |
| P04220 | Ig mu heavy chain disease protein | 43,057 | 22/35 | 52.94 | 12,444.26 |
| P01834 | Ig kappa chain C region | 11,609 | 7/7 | 80.19 | 26,627.65 |
| P01614 | Ig kappa chain VII region Cum | 12,676 | 1/7 | 11.30 | 787.52 |
| P06309 | Ig kappa chain VII region GM607 Fragment | 12,664 | 2/5 | 31.62 | 567.77 |
| P06310 | Ig kappa chain VII region RPMI 6410 | 14,707 | 2/7 | 29.32 | 622.24 |
| P06617 | Ig kappa chain V II region TEW | 2,059 | 2/5 | 32.74 | 571.31 |
| P04206 | Ig kappa chain VIII region GOL | 11,830 | 2/8 | 31.19 | 1,520.77 |
| P18135 | Ig kappa chain VIII region HAH | 14,073 | 2/8 | 26.36 | 1,260.29 |
| P18136 | Ig kappa chain VIII region HIC | 14,089 | 2/7 | 26.36 | 1,260.29 |
| P01621 | Ig kappa chain VIII region NG9 Fragment | 10,729 | 2/6 | 56.00 | 590.59 |
| P01620 | Ig kappa chain VIII region SIE | 11,775 | 4/6 | 66.06 | 1,600.43 |
| P01623 | Ig kappa chain VIII region WOL | 11,746 | 3/7 | 51.38 | 1,622.15 |
| P01622 | Ig kappa chain VIII region TI | 11,778 | 3/6 | 51.38 | 1,520.77 |
| P04206 | Ig kappa chain VIII region GOL | 11,830 | 2/8 | 31.19 | 1,520.77 |
| P0CG04 | Ig lambda 1 chain C region | 11,348 | 5/7 | 65.09 | 38,924.68 |
| P0CG05 | Ig lambda 2 chain C region | 11,294 | 6/7 | 77.36 | 39,000.63 |
| P0CG06 | Ig lambda 3 chain C region | 11,238 | 5/7 | 76.42 | 39,000.63 |
| P0CF74 | Ig lambda 6 chain C region | 11,277 | 5/6 | 77.36 | 24,818.13 |
| A0M8Q6 | Ig lambda 7 chain C region | 11,303 | 4/7 | 46.23 | 24,610.28 |
| P01591 | Immunoglobulin J chain | 18,099 | 4/11 | 34.59 | 1,818.20 |
| P35858 | Insulin like growth factor binding protein complex acid labile subunit | 66,035 | 6/35 | 12.56 | 119.96 |
| B9A064 | Immunoglobulin lambda like polypeptide 5 | 23,063 | 6/12 | 42.99 | 38,934.43 |
| P19827 | Inter-alpha trypsin inhibitor heavy chain H1 | 101,389 | 19/56 | 31.61 | 1,735.56 |
| P19823 | Inter-alpha trypsin inhibitor heavy chain H2 | 106,464 | 21/70 | 32.77 | 1,415.98 |
| Q14624 | Inter-alpha trypsin inhibitor heavy chain H4 | 103,358 | 22/64 | 40.00 | 1,410.90 |
| Q5T749 | Keratinocyte proline rich protein | 64,136 | 1/29 | 9.33 | 133.79 |
| P01042 | Kininogen 1 | 71,958 | 13/61 | 39.13 | 1,470.83 |
| P02750 | Leucine-rich alpha-2-glycoprotein | 38,178 | 6/24 | 26.80 | 925.55 |
| O15165 | Low-density lipoprotein receptor class A domain containing protein | 33,900 | 2/19 | 12.42 | 142.67 |
| Q96PD5 | N acetylmuramoyl L alanine amidase | 62,217 | 7/36 | 23.61 | 381.10 |
| Q13516 | Oligodendrocytetranscriptionfactor2 | 32,385 | 2/16 | 20.74 | 356.38 |
| P05155 | Plasma protease C1 inhibitor | 55,154 | 7/29 | 21.60 | 1,325.77 |
| P00747 | Plasminogen | 90,569 | 15/63 | 26.91 | 318.40 |
| P02775 | Platelet basic protein | 13,894 | 3/9 | 46.09 | 801.19 |
| P20742 | Pregnancy zone protein | 163,863 | 16/87 | 21.52 | 1,774.43 |
| P02760 | Protein AMBP | 38,999 | 10/26 | 37.78 | 2,146.99 |
| Q9UJC3 | Protein Hook homolog 1 | 84,648 | 8/69 | 13.87 | 65.59 |
| P00734 | Prothrombin | 70,037 | 14/47 | 35.69 | 1,449.93 |
| Q9H5L9 | Putative uncharacterized protein C5orf66 | 1,557 | 1/8 | 24.83 | 115.20 |
| O00472 | RNA polymerase II elongation factor ELL2 | 7,232 | 5/74 | 9.69 | 163.86 |
| Q9NP77 | RNA polymerase II subunit A C terminal domain phosphatase SSU72 | 22,575 | 7/17 | 43.30 | 179.28 |
| Q96HS1 | Serine threonine protein phosphatase PGAM5 mitochondrial | 32,005 | 3/23 | 11.76 | 229.10 |
| P02787 | Serotransferrin | 77,064 | 42/76 | 72.78 | 42,299.91 |
| P02768 | Serum albumin | 69,367 | 54/55 | 38.92 | 4,317.47 |
| P27169 | Serum paraoxonase arylesterase 1 | 39,731 | 7/18 | 50.99 | 2,611.12 |
| P04278 | Sex hormone binding globulin | 43,779 | 4/29 | 25.62 | 210.35 |
| O00337 | Sodium nucleoside cotransporter | 71,584 | 3/35 | 3.39 | 102.95 |
| Q13596 | Sortingnexin1 | 5,907 | 3/40 | 11.88 | 178.19 |
| O60235 | Transmembrane protease serine 11D | 46,264 | 2/20 | 11.48 | 122.25 |
| P02766 | Transthyretin | 15,887 | 4/9 | 50.34 | 302.37 |
| Q9NZQ9 | Tropomodulin 4 | 39,336 | 3/32 | 26.09 | 192.01 |
| Q5SQH8 | Uncharacterized protein C6orf 136 | 35,794 | 2/16 | 29.84 | 122.10 |
| Q8N865 | Uncharacterized protein C7orf 31 | 68,465 | 4/49 | 12.03 | 47.34 |
| Q6UXV3 | Uncharacterized protein UNQ6126 | 16,883 | 1/8 | 36.31 | 161.41 |
| P02774 | Vitamin D binding protein | 52,964 | 24/45 | 67.93 | 3,508.70 |
| P04004 | Vitronectin | 54,306 | 10/28 | 38.49 | 2,808.10 |
| P25311 | Zinc alpha-2-glycoprotein | 34,259 | 9/27 | 48.66 | 2,246.30 |
| P21506 | Zinc finger protein 10 | 66,455 | 4/45 | 9.60 | 220.02 |
| Q86UK7 | Zinc finger protein 598 | 98,637 | 6/71 | 10.18 | 161.99 |
Abbreviations: AMBP, alpha-1-microglobulin; LC–MSE, liquid chromatography–data-independent label-free mass spectrometry.